Several times in a row this happened when using an ICE50 connected via USB:
I set a breakpoint in a working project (code runs ok) and then convert the breakpoint to a watchpoint. I then try and run again and I get a fatal error:
"AVRStudio MFC Application has encountered a problem and needs to close. We are sorry for the inconvenience.
AppName: avrstudio.exe AppVer: 188.8.131.520 ModName: kernel32.dll
ModVer: 5.1.2600.1106 Offset: 0001ab10"
I send the auto-error report to Microsoft (just for kicks) and the app closes. If I do this a few times, my entire PC does a hard RESET!!!!